The efficient cyclization reactions of the N-methanesulfonyl or N-ethoxycarbonyl derivatives of 2-ethynylanilines, functionalized on the benzene ring and/or the acetylene terminal into indoles catalyzed by either Cu(OTf)2 or Cu(OAc)2 are accomplis...
Bioorganic and Medicinal Chemistry 10(10) 3229-3236 2002年 [査読有り]
The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played import...
The regioselectivity of the cyclization reaction of 2-ethynylbenzyl alcohol and 2-ethynylbenzylamine derivatives promoted by TBAF was investigated. Six-membered ring derivatives were obtained from the compounds, which have a butyl group on the tri...
Journal of the Chemical Society, Perkin Transactions 1 (24) 4339-4346 2000年 [査読有り]
Vignafuran 2, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester 3, and coumestrol 4 were efficiently synthesized from the same starting material, 4-bromoresorcinol 14a, through the common intermediate, diarylacetylen...
CHEMICAL COMMUNICATIONS (21) 2197-2198 1999年11月 [査読有り]
The first enanticontrolled synthesis of five naturally occurring polyoxygenated cyclohexenylmethanol dibenzoates has been achieved to confirm three [(-)-zeylenol, (-)-uvarigranol G, (+)-pipoxide], revise one [(-)-tonkinenin A] and disprove one [(-...