An air- and moisture-stable nickel(II) complex of bis-carbene pincer complex 2 has been synthesized, and its catalytic activity for the Heck reaction and the Suzuki coupling reaction was investigated.
The reaction conditions for the Pd-catalyzed cyclization reaction of 2-(2-carbomethoxyethynyl)aniline derivatives were investigated. The amounts of Pd(PPh3)(4), methyl propiolate, and ZnBr2 could be significantly reduced compared with those report...
CHEMICAL & PHARMACEUTICAL BULLETIN 53(11) 1502-1507 2005年11月 [査読有り]
We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In ...
K Hiroya   S Itoh   T Sakamoto   
TETRAHEDRON 61(46) 10958-10964 2005年11月 [査読有り]
Results of the optimized cyclization reaction of 2-ethynyl aniline derivatives to indoles catalyzed by copper(II) salts are described. The reactions can be carried out in a mixture of H2O and MeOH in the presence of 1-ethylpiperidine at room tempe...
K Hiroya   T Takahashi   K Shimomae   T Sakamoto   
CHEMICAL & PHARMACEUTICAL BULLETIN 53(2) 207-213 2005年2月 [査読有り]
The stereoselective introduction of an allyl group into the angular position of 2-(TBS-oxymethyl)-2,3,4,6,7,8hexahydro-l-benzopyran-5-one was accomplished using Birch reduction and an enolate trapping reaction. It was determined that the allyl gro...