K Hiroya   S Matsumoto   T Sakamoto   
ORGANIC LETTERS 6(17) 2953-2956 2004年8月 [査読有り]
The sequential coupling and cyclization reactions between aryl halides and methyl propiolate were investigated. The electron-withdrawing groups on the aromatic ring are essential for producing the methyl indole-2-carboxylate derivatives. On the ot...
K Inamoto   M Katsuno   T Yoshino   Suzuki, I   K Hiroya   T Sakamoto   
CHEMISTRY LETTERS 33(8) 1026-1027 2004年8月 [査読有り]
The efficient method for the preparation of 3-substituted indazoles was developed using the palladium catalyzed intra-molecular amination reaction of 2-bromophenyl hydrazone derivatives. Good functional group compatibility was observed under mild ...
K Hiroya   S Itoh   T Sakamoto   
JOURNAL OF ORGANIC CHEMISTRY 69(4) 1126-1136 2004年2月 [査読有り]
The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated. Cu(OAc)(2) has been proved to be the best catalyst for the synthesis of various 1-p-tolylsulfonyl or 1-methylsulfonylin...
The reaction of N-tosyl-2-pyridinone with tert-butyldimethylsilyl ketene acetal, catalyzed by a Lewis acid, has been investigated. While both the C-4 Michael adduct 3 and the bicyclic compound 5 were isolated from aluminum chloride- or trimethylal...