Drug Metabolism Division of ASPET, James R. Gillette Drug Metabolism Best Paper of 2013,Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic EnzymesToshiyuki Kudo Akihiro Hisaka Yuichi Sugiyama Kiyomi Ito
Yoshiaki Yamagishi   Rei Saiki   Takeshi Yoshimi   Toshiyuki Kudo   Kiyomi Ito   
Nutrients 13(9) 2021年9月
We have previously shown that two enteral nutrition formulas suppressed gastric lesions induced by the oral administration of indomethacin (IND) in mice. However, the mechanism of their protective effect is unknown. In this study, the effect of th...
PURPOSE: Menkes disease is a rare hereditary disease in which systemic deficiency of copper due to mutation of the ATP7A gene causes severe neurodegenerative disorders. The present parenteral drugs have limited efficacy, so there is a need for an ...
Keiichi Morita   Motohiro Kato   Toshiyuki Kudo   Kiyomi Ito   
Xenobiotica; the fate of foreign compounds in biological systems 50(9) 1064-1075 2020年9月 [査読有り]
In vitro-in vivo extrapolation (IVIVE) using human liver microsomes has been widely used to predict metabolic clearance, but some of the factors used in the process of prediction show variability for the same compound: notably, microsomal intrinsi...
Yoshiaki Yokoyama   Naoto Hosokawa   Toshiyuki Kudo   Hitomi Goda   Kiyomi Ito   Masanori Suzuki   Ryohkan Funakoshi   
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 26(3) 285-288 2020年3月 [査読有り]
Ceftriaxone (CTRX) is a third-generation cephalosporin commonly used to treat infections such as community-acquired pneumonia and urinary tract infections caused by mainly Gram-negative bacteria and some Gram-positive bacteria. Here, we report a c...
Takeshi Yoshimi   Yoshiaki Yamagishi   Issei Kanegawa   Megumi Suda   Rei Saiki   Ken-Ichiro Tanaka   Hitomi Goda   Toshiyuki Kudo   Kiyomi Ito   
Nutrients 11(12) 2019年12月 [査読有り]
We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7-9 weeks old were fasted, then orally given either purified water, Mermed® One, or 2-fold...