工藤敏之

研究者氏名	工藤敏之
	クドウトシユキ
URL
所属	武蔵野大学
部署	薬学部薬学科
職名	講師
学位	学士(星薬科大学), 修士(星薬科大学大学院), 博士(星薬科大学大学院)
J-Global ID	201701007072398063

研究キーワード

薬物動態・代謝学

研究分野

ライフサイエンス / 医療薬学 /

経歴

2015年4月

現在

武蔵野大学薬学部薬学科講師

2010年4月

2015年3月

武蔵野大学薬学部薬学科助教

2010年4月

2015年3月

武蔵野大学大学院薬学研究科助教

2010年4月

2015年3月

武蔵野大学薬学部助教

学歴

2007年4月

2010年3月

星薬科大学大学院

2005年4月

2007年3月

星薬科大学大学院

2001年4月

2005年3月

星薬科大学薬学部

2001年3月

私立市川高等学校

委員歴

2022年4月

現在

日本薬剤学会出版委員会

2016年4月

現在

日本薬剤学会薬物相互作用FG 執行部

受賞

2014年1月

Drug Metabolism Division of ASPET, James R. Gillette Drug Metabolism Best Paper of 2013,Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic Enzymes
Toshiyuki Kudo Akihiro Hisaka Yuichi Sugiyama Kiyomi Ito

2007年9月

第24回和漢医薬学会大会優秀発表賞受賞

論文

<2 345 6 >

Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.

Tomohisa Nakada Toshiyuki Kudo Toshiyuki Kume Hiroyuki Kusuhara Kiyomi Ito

Drug metabolism and pharmacokinetics 33(1) 103-110 2018年2月 [査読有り]

Serum creatinine (SCr) levels rise during trimethoprim therapy for infectious diseases. This study aimed to investigate whether the elevation of SCr can be quantitatively explained using a physiologically-based pharmacokinetic (PBPK) model incorpo...

Estimation of the Contribution of CYP2C8 and CYP3A4 in Repaglinide Metabolism by Human Liver Microsomes Under Various Buffer Conditions.

Toshiyuki Kudo Hitomi Goda Yuki Yokosuka Ryo Tanaka Seina Komatsu Kiyomi Ito

Journal of pharmaceutical sciences 106(9) 2847-2852 2017年9月 [査読有り]

We have previously reported that the microsomal activities of CYP2C8 and CYP3A4 largely depend on the buffer condition used in in vitro metabolic studies, with different patterns observed between the 2 isozymes. In the present study, therefore, th...

Effect of buffer conditions on CYP2C8-mediated paclitaxel 6α-hydroxylation and CYP3A4-mediated triazolam α- and 4-hydroxylation by human liver microsomes.

Toshiyuki Kudo Yuya Ozaki Tomomi Kusano Eri Hotta Yuka Oya Seina Komatsu Hitomi Goda Kiyomi Ito

Xenobiotica; the fate of foreign compounds in biological systems 46(3) 241-6 2016年 [査読有り]

1. Buffer conditions in in vitro metabolism studies using human liver microsomes (HLM) have been reported to affect the metabolic activities of several cytochrome P450 (CYP) isozymes in different ways, although there are no reports about the depen...

Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study.

Kazuhisa Ozeki Motohiro Kato Yuuji Sakurai Masaki Ishigai Toshiyuki Kudo Kiyomi Ito

International journal of pharmaceutics 495(2) 963-71 2015年11月 [査読有り]

In a transcellular transport study, the apparent permeability coefficient (Papp) of a compound is evaluated using the range by which the amount of compound accumulated on the receiver side is assumed to be proportional to time. However, the time p...

Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.

Toshiyuki Kudo Yumiko Endo Rina Taguchi Masami Yatsu Kiyomi Ito

Xenobiotica; the fate of foreign compounds in biological systems 45(5) 413-9 2015年5月 [査読有り]

1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ), an antiprotozoal imidazole derivative. 2. To elucidate the mechanism of this interaction and to identify other possible drug-dru...