Drug Metabolism Division of ASPET, James R. Gillette Drug Metabolism Best Paper of 2013,Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic EnzymesToshiyuki Kudo Akihiro Hisaka Yuichi Sugiyama Kiyomi Ito
Drug metabolism and pharmacokinetics 33(1) 103-110 2018年2月 [査読有り]
Serum creatinine (SCr) levels rise during trimethoprim therapy for infectious diseases. This study aimed to investigate whether the elevation of SCr can be quantitatively explained using a physiologically-based pharmacokinetic (PBPK) model incorpo...
Toshiyuki Kudo   Hitomi Goda   Yuki Yokosuka   Ryo Tanaka   Seina Komatsu   Kiyomi Ito   
Journal of pharmaceutical sciences 106(9) 2847-2852 2017年9月 [査読有り]
We have previously reported that the microsomal activities of CYP2C8 and CYP3A4 largely depend on the buffer condition used in in vitro metabolic studies, with different patterns observed between the 2 isozymes. In the present study, therefore, th...
Toshiyuki Kudo   Yuya Ozaki   Tomomi Kusano   Eri Hotta   Yuka Oya   Seina Komatsu   Hitomi Goda   Kiyomi Ito   
Xenobiotica; the fate of foreign compounds in biological systems 46(3) 241-6 2016年 [査読有り]
1. Buffer conditions in in vitro metabolism studies using human liver microsomes (HLM) have been reported to affect the metabolic activities of several cytochrome P450 (CYP) isozymes in different ways, although there are no reports about the depen...
International journal of pharmaceutics 495(2) 963-71 2015年11月 [査読有り]
In a transcellular transport study, the apparent permeability coefficient (Papp) of a compound is evaluated using the range by which the amount of compound accumulated on the receiver side is assumed to be proportional to time. However, the time p...
Xenobiotica; the fate of foreign compounds in biological systems 45(5) 413-9 2015年5月 [査読有り]
1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ), an antiprotozoal imidazole derivative. 2. To elucidate the mechanism of this interaction and to identify other possible drug-dru...