Drug Metabolism Division of ASPET, James R. Gillette Drug Metabolism Best Paper of 2013,Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic EnzymesToshiyuki Kudo Akihiro Hisaka Yuichi Sugiyama Kiyomi Ito
Toshiyuki Kudo   Akihiro Hisaka   Yuichi Sugiyama   Kiyomi Ito   
Drug metabolism and disposition: the biological fate of chemicals 41(2) 362-71 2013年2月 [査読有り]
The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based on a physiologically based pharmacokinetic (PB...
Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ...
Nobutomo Ikarashi   Toshihide Mochiduki   Ayaka Takasaki   Takashi Ushiki   Kohta Baba   Makoto Ishii   Toshiyuki Kudo   Kiyomi Ito   Takahiro Toda   Wataru Ochiai   Kiyoshi Sugiyama   
Life sciences 88(3-4) 194-200 2011年1月 [査読有り]
AIMS: We have suggested that an osmotic laxative, magnesium sulphate (MgSO(4)), may act as a cathartic in a very rational manner by increasing the aquaporin 3 (AQP3) expression level and by changing osmotic pressure in the colon. In this study, we...
Aquaporin (AQP) 3 plays an important role in regulating faecal water content in the colon. We investigated the role of AQP3 in the colon in the laxative effect of magnesium sulphate (MgSO(4)), a widely used osmotic laxative. Rats were administered...