Trace elements such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn) are absorbed from food via the gastrointestinal tract, transported into the brain, and play central roles in normal brain functions. An excess of these trace elements oft...
Journal of clinical biochemistry and nutrition 71(1) 7-15 2022年7月
Copper and zinc are essential for normal brain functions. Both are localized in presynaptic vesicles and are secreted into synaptic clefts during neuronal excitation. Despite their significance, excesses of copper and zinc are neurotoxic. In parti...
Midori Kato-Negishi Jun Sawayama Masahiro Kawahara Shoji Takeuchi
Scientific Reports 12(1) 2022年5月
Abstract
For the establishment of a reproducible and sensitive assay system for three-dimensional (3D) tissue-based drug screening, it is essential to develop 3D tissue arrays with uniform shapes and high cell numbers that prevent cell death in t...
International Journal of Molecular Sciences 22(14) 7242-7242 2021年7月
Copper is an essential trace element and possesses critical roles in various brain functions. A considerable amount of copper accumulates in the synapse and is secreted in neuronal firings in a manner similar to zinc. Synaptic copper and zinc modu...
Y. Morimoto Y. Morimoto M. Kato-Negishi H. Onoe H. Onoe S. Takeuchi S. Takeuchi
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 2 789-791 2011年12月
We propose aligned free-standing skeletal muscle fibers connecting with neurons. By confining skeletal cells, C2C12, with collagen gel into polydimethylsiloxane (PDMS) trenches, we successfully formed the muscle fibers that are highly oriented to ...
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