The first successful example of a catalytic asymmetric cyclopropanation with α-diazopropionates is described. The cyclopropanation reaction of 1-aryl-substituted and related conjugated alkenes with tert-butyl α-diazopropionate has been achieved by...
Angewandte Chemie - International Edition 50(30) 6803-6808 2011年 [査読有り]
Two rhodium(II) ions work together: [Rh2(S-tbpttl)4] is an exceptionally effective catalyst for enantioselective cyclopropenation reactions of 1-alkynes with α-alkyl-α-diazoacetates (see scheme). Cyclopropenation is preferred over alkene formation...
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (35) 6850-6854 2010年12月 [査読有り]
A new route to the diarylheptanoid diospongins A and B was developed. The key step is a novel, one-pot, sequential dirhodium(II) tetrakis[(S)-3-(benzo-fused phthalimido)-2-piperidinonate] [Rh-2(S-BPTPI)(4)] catalyzed enantioselective hetero-Diels-...
A catalytic asymmetric synthesis of descurainin has been achieved by incorporating an enantioselective 1,3-dipolar cycloaddition, a stereoselective alkene hydrogenation, an oxidation with Fremy's salt and a regioselective demethylation with NbCl5 ...
JOURNAL OF ORGANIC CHEMISTRY 75(17) 6039-6042 2010年9月 [査読有り]
The reaction of a six-membered cyclic formyl-carbonyl ylide derived from alpha-diazo-beta-ketoester with phenylacetylene derivatives under the catalysis of dirhodium(II) tetrakis[N-tetra-chlorophthaloyl-(S)-tert-leucinate], Rh-2(S-TCPTTL)4, provid...