Jun Shi   Georg Manolikakes   Chien Hung Yeh   Carlos A. Guerrero   Ryan A. Shenvi   Hiroki Shigehisa   Phil S. Baran   
Journal of the American Chemical Society 133(20) 8014-8027 2011年5月 [査読有り]
Full details are provided for an improved synthesis of cortistatin A and related structures as well as the underlying logic and evolution of strategy. The highly functionalized cortistatin A-ring embedded with a key heteroadamantane was synthesize...
Jun Shi   Hiroki Shigehisa   Carlos A. Guerrero   Ryan A. Shenvi   Chuang Chuang Li   Phil S. Baran   
Angewandte Chemie - International Edition 48(24) 4328-4331 2009年6月 [査読有り]
One stereocenter makes all the difference: The synthesis and biological evaluation of 17-epi-cortistatin A is reported from a common intermediate used to procure natural cortistatin A. The synthesis features a unique stereocontrolled Raney-Ni redu...
Archiv der Pharmazie 341(9) 578-583 2008年9月 [査読有り]
Optically pure N-Boc-norpandamarilactonine-B was diastereoselectively synthesized starting from L-serine by employing a double ring closing metathesis (RCM) of a tetraene derivative as a key reaction. N-Boc-norpandamarilactonine-B obtained was fur...
An exceptional intramolecular palladium-catalyzed alkenylation of silyl enol ether in the absence of a fluoride additive was developed, and this reaction led to the construction of bicyclo[3.3.1]nonane ring system in reasonable yield. In this type...
8',9'-Dimethoxy-1',5',6',10b'-tetrahydro-4H-spiro(cyclohexa-2,5-diene-1,2'-pyrrolo[2,1-a]isoquinoline)-3',4-dione 2 with a basic skeleton of a natural product, annnosqualine, exhibited unique behavior in a dienone-phenol rearrangement. Treatment o...