Hisashi Yoshida   Sam-Yong Park   Gyosuke Sakashita   Yuko Nariai   Kanako Kuwasako   Yutaka Muto   Takeshi Urano   Eiji Obayashi   
Nat Commun. 11(1) 4744-4752 2020年9月 [査読有り]
The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation of U2AF1 can cause seri...
The spliceosomal protein SF3b49, a component of the splicing factor 3b (SF3b) protein complex in the U2 small nuclear ribonucleoprotein, contains two RNA recognition motif (RRM) domains. In yeast, the first RRM domain (RRM1) of Hsh49 protein (yeas...
Jean-Baptiste Duvignaud   Mikael Bedard   Takashi Nagata   Yutaka Muto   Shigeyuki Yokoyama   Stephane M. Gagne   Michel Vincent   
BIOCHEMISTRY 55(18) 2553-2566 2016年5月 [査読有り]
p54(nrb)/NonO is a nuclear RNA-binding protein involved in many cellular events such as pre-mRNA processing, transcription, and nuclear retention of hyper-edited RNAs. In particular, it participates in the splicing process by directly binding the ...
Hisashi Yoshida   Sam-Yong Park   Takashi Oda   Taeko Akiyoshi   Mamoru Sato   Mikako Shirouzu   Kengo Tsuda   Kanako Kuwasako   Satoru Unzai   Yutaka Muto   Takeshi Urano   Eiji Obayashi   
GENES & DEVELOPMENT 29(15) 1649-1660 2015年8月 [査読有り]
The pre-mRNA splicing reaction of eukaryotic cells has to be carried out extremely accurately, as failure to recognize the splice sites correctly causes serious disease. The small subunit of the U2AF heterodimer is essential for the determination ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112(17) E2217-E2224 2015年4月 [査読有り]
D-Serine is an essential coagonist with glutamate for stimulation of N-methyl-D-aspartate (NMDA) glutamate receptors. Although astrocytic metabolic processes are known to regulate synaptic glutamate levels, mechanisms that control D-serine levels ...