JOURNAL OF BIOLOGICAL CHEMISTRY 288(21) 14886-14905 2013年5月 [査読有り]
Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the involvement of RNA recognition motifs (RRMs) in TDP-43 proteinopathy, it rema...
RNA helicase A (RHA) is a multifunctional protein that regulates gene expression. RHA has two double-stranded RNA-binding domains (dsRBDs) that serve as modules for highly structured RNA binding and protein-protein interactions. Using the dsRBDs, ...
Ji-Hyang Ha   Jae-Sun Shin   Mi-Kyung Yoon   Min-Sung Lee   Fahu He   Kwang-Hee Bae   Ho Sup Yoon   Chong-Kil Lee   Sung Goo Park   Yutaka Muto   Seung-Wook Chi   
Journal of Biological Chemistry 288(10) 7387-7398 2013年3月 [査読有り]
Background: Interactions between p53 and Bcl-2 family proteins serve a critical role in transcription-independent p53 apoptosis. Results: We studied the interactions of p53TAD2 with anti-apoptotic Bcl-2 family proteins at the atomic level by NMR, ...
The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for ...
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 80(6) 1699-1706 2012年6月
RNA helicase A (RHA) is a highly conserved protein with multifaceted functions in the gene expression of cellular and viral mRNAs. RHA recognizes highly structured nucleotides and catalytically rearranges the various interactions between RNA, DNA,...