The TAR RNA-binding Protein (TRBP) is a double-stranded RNA (dsRNA)-binding protein, which binds to Dicer and is required for the RNA interference pathway. TRBP consists of three dsRNA-binding domains (dsRBDs). The first and second dsRBDs (dsRBD1 ...
The zinc finger CW (zf-CW) domain is a motif of about 60 residues that is frequently found in proteins involved in epigenetic regulation. Here, we determined the NMR solution structure of the zf-CW domain of the human zf-CW and PWWP domain contain...
JOURNAL OF MOLECULAR BIOLOGY 393(2) 478-495 2009年10月 [査読有り]
The Notch signaling pathway is critical for many developmental processes and requires complex trafficking of both Notch receptor and its ligands, Delta and Serrate. In Drosophila melanogaster, the endocytosis of Delta in the signal-sending cell is...
Helena Hernandez   Olga V. Makarova   Evgeny M. Makarov   Nina Morgner   Yutaka Muto   Daniel Pomeranz Krummel   Carol V. Robinson   
PLOS ONE 4(9) e7202 2009年9月 [査読有り]
Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RN...
NUCLEIC ACIDS RESEARCH 37(15) 5151-5166 2009年8月 [査読有り]
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation. Several target RNA sequences of CUG-BP1 have b...