G. Ishikawa   Y. Koya   H. Tanaka   Y. Nagakura   
OSTEOARTHRITIS AND CARTILAGE 23(6) 925-932 2015年6月 [査読有り]
Objective: Osteoarthritis (OA) patients experience exaggerated pain during movements such as walking. Anti-nerve growth factor (NGF) antibodies have recently shown analgesic effects in OA patients. We examined the effect of a single dose of anti-N...
Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an eti...
EXPERT OPINION ON DRUG DISCOVERY 10(10) 1043-1045 2015年 [査読有り]
'Dysfunctional pain', a type of chronic pain, is associated with a broad range of clinical disorders, including fibromyalgia, irritable bowel syndrome and interstitial cystitis. It is emerging as a serious issue due to the negative impact of inexp...
Go Ishikawa   Yukinori Nagakura   Nobuaki Takeshita   Yasuaki Shimizu   
EUROPEAN JOURNAL OF PHARMACOLOGY 738 111-117 2014年9月 [査読有り]
Patients with osteoarthritis (OA) suffer from joint pain aggravated by movement, which affect their quality of life. In the present study, a weight bearing paradigm for pain at rest and a gait paradigm for pain during movement were tested in rats ...
Pharmacology Biochemistry and Behavior 108 8-15 2013年 [査読有り]
Fibromyalgia is a prevalent musculoskeletal disorder characterized by chronic widespread pain that significantly reduces quality of life in patients. Due to the lack of consistently effective treatment, the development of improved therapies for tr...