S. Kawasaki-Yatsugi   Y. Nagakura   S. Ogino   T. Sekizawa   T. Kiso   M. Takahashi   G. Ishikawa   H. Ito   Y. Shimizu   
EUROPEAN JOURNAL OF PAIN 16(10) 1426-1436 2012年11月 [査読有り]
Background The withdrawal response elicited by a nociceptive stimulus, i.e., evoked pain measure, is commonly used as an efficacy endpoint in neuropathic pain animal models. It, however, has several limitations, which highlight the importance of e...
BEHAVIOURAL BRAIN RESEARCH 226(1) 242-249 2012年1月 [査読有り]
The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms. The present study explored the pathophysiology underlying the pain symptoms in the RIM rat and the chronic constriction injury (CCI) rat, an animal model of...
The paradigm of sine-wave electrical stimuli has been used for sensory neurological assessment in humans. In the present study, we applied the paradigm to the dog for the quantitative assessment of sensory function. Sine-wave electrical current st...
T. Oe   M. Tsukamoto   Y. Nagakura   
NEUROSCIENCE 169(4) 1860-1871 2010年9月 [査読有り]
The present study investigated the precise relationship between brain biogenic amine (dopamine, noradrenaline, and serotonin) tones and nociception. Nociceptive sensitivities to multimodal (muscle pressure, tactile, cold, and heat) stimuli were as...