JOURNAL OF TOXICOLOGICAL SCIENCES 41(2) 273-279 2016年4月 [査読有り]
Macrophages induce the innate immunity by recognizing pathogens through Toll-like receptors (TLRs), which sense pathogen-associated molecular patterns. Myeloid differentiation factor 88 (MyD88), which is an essential adaptor molecule for most TLRs...
The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungi...
Body and excrement extracts from Dermatophagoides Prime were used to study stimulation of Toll-like receptors (TLRs). The excrement extract stimulated nuclear factor (NF)-kappa B-dependent reporter activity to an extent similar to lipopolysacchari...
Naina Shah Montserrat Montes de Oca Maria Jover-Cobos Ken-ichi Tanamoto Masashi Muroi Kei-ichi Sugiyama Nathan A. Davies Rajeshwar P. Mookerjee Dipok Kumar Dhar Rajiv Jalan
Strategies for the prevention of multiorgan dysfunction (MOD) in acetaminophen (APAP)-induced acute liver failure (ALF) are an unmet need. Our study tested the hypothesis that sterile inflammation induced by APAP in a mouse model would activate to...
PATHOGENS AND DISEASE 67(3) 199-205 2013年4月 [査読有り]
We investigated the difference in the effect of synthetic lipid A compounds on MyD88-dependent and -independent Toll-like receptor 4 (TLR4) signaling in mouse macrophage cells. At higher concentrations, Escherichia coli-type hexa-acylated lipid A ...
The effects of the soluble forms of the endotoxin receptor molecules sMD-2 and sCD14 on bacterial growth were studied. When Escherichia coli and Bacillus subtilis were incubated at 37 degrees C for 18 hr with either sMD-2 or sCD14, growth of these...
Deoxynivalenol (DON) and nivalenol (NIV), trichothecene mycotoxins, are secondary metabolites produced by Fusarium fungi. Trichothecene mycotoxins cause immune dysfunction, thus leading to diverse responses to infection. The present study evaluate...
Yoshida T Yoshioka Y Fujimura M Kayamuro H Yamashita K Higashisaka K Nakanishi R Morishita Y Nabeshi H Yamashita T Muroi M Tanamoto K Nagano K Abe Y Kamada H Kawai Y Mayumi T Itoh N Yoshikawa T Tsunoda S Tsutsumi Y
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