JOURNAL OF TOXICOLOGICAL SCIENCES 41(2) 273-279 2016年4月 [査読有り]
Macrophages induce the innate immunity by recognizing pathogens through Toll-like receptors (TLRs), which sense pathogen-associated molecular patterns. Myeloid differentiation factor 88 (MyD88), which is an essential adaptor molecule for most TLRs...
The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungi...
Body and excrement extracts from Dermatophagoides Prime were used to study stimulation of Toll-like receptors (TLRs). The excrement extract stimulated nuclear factor (NF)-kappa B-dependent reporter activity to an extent similar to lipopolysacchari...
Naina Shah   Montserrat Montes de Oca   Maria Jover-Cobos   Ken-ichi Tanamoto   Masashi Muroi   Kei-ichi Sugiyama   Nathan A. Davies   Rajeshwar P. Mookerjee   Dipok Kumar Dhar   Rajiv Jalan   
Strategies for the prevention of multiorgan dysfunction (MOD) in acetaminophen (APAP)-induced acute liver failure (ALF) are an unmet need. Our study tested the hypothesis that sterile inflammation induced by APAP in a mouse model would activate to...
PATHOGENS AND DISEASE 67(3) 199-205 2013年4月 [査読有り]
We investigated the difference in the effect of synthetic lipid A compounds on MyD88-dependent and -independent Toll-like receptor 4 (TLR4) signaling in mouse macrophage cells. At higher concentrations, Escherichia coli-type hexa-acylated lipid A ...
Food manufacturing enzymes are named according to enzyme functions in Japan. Active enzyme proteins are not identified as substances. Therefore, in the List of Existing Food Additives, most items consist of enzymes from different origins. If a che...
Akiyama T   Hayashi A   Yamazaki T   Tada A   Sugimoto N   Yun YS   Kunugi A   Kawamura Y   
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1792(10) 1011-1018 2009年10月
Endothelial cell injury/dysfunction is considered to play a critical role in the pathogenesis of severe sepsis and septic shock. Although it is considered that endothelial cell apoptosis is involved in endothelial injury/dysfunction. physiological...
Cepaic acid was isolated as a novel xanthylium yellow pigment from the dried outer scales of the yellow onion Allium cepa Linne. Its structure was elucidated on the basis of ESI-MS and 2D NMR spectroscopy as a 9-carboxy-1,3,6,8-tetrahydroxyxanthyl...