JOURNAL OF TOXICOLOGICAL SCIENCES 41(2) 273-279 2016年4月 [査読有り]
Macrophages induce the innate immunity by recognizing pathogens through Toll-like receptors (TLRs), which sense pathogen-associated molecular patterns. Myeloid differentiation factor 88 (MyD88), which is an essential adaptor molecule for most TLRs...
The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungi...
Body and excrement extracts from Dermatophagoides Prime were used to study stimulation of Toll-like receptors (TLRs). The excrement extract stimulated nuclear factor (NF)-kappa B-dependent reporter activity to an extent similar to lipopolysacchari...
Naina Shah   Montserrat Montes de Oca   Maria Jover-Cobos   Ken-ichi Tanamoto   Masashi Muroi   Kei-ichi Sugiyama   Nathan A. Davies   Rajeshwar P. Mookerjee   Dipok Kumar Dhar   Rajiv Jalan   
Strategies for the prevention of multiorgan dysfunction (MOD) in acetaminophen (APAP)-induced acute liver failure (ALF) are an unmet need. Our study tested the hypothesis that sterile inflammation induced by APAP in a mouse model would activate to...
PATHOGENS AND DISEASE 67(3) 199-205 2013年4月 [査読有り]
We investigated the difference in the effect of synthetic lipid A compounds on MyD88-dependent and -independent Toll-like receptor 4 (TLR4) signaling in mouse macrophage cells. At higher concentrations, Escherichia coli-type hexa-acylated lipid A ...
Tada A   Sugimoto N   Sato K   Akiyama T   Asanoma M   Yun YS   Yamazaki T   Tanamoto K