JOURNAL OF TOXICOLOGICAL SCIENCES 41(2) 273-279 2016年4月 [査読有り]
Macrophages induce the innate immunity by recognizing pathogens through Toll-like receptors (TLRs), which sense pathogen-associated molecular patterns. Myeloid differentiation factor 88 (MyD88), which is an essential adaptor molecule for most TLRs...
The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungi...
Body and excrement extracts from Dermatophagoides Prime were used to study stimulation of Toll-like receptors (TLRs). The excrement extract stimulated nuclear factor (NF)-kappa B-dependent reporter activity to an extent similar to lipopolysacchari...
Naina Shah   Montserrat Montes de Oca   Maria Jover-Cobos   Ken-ichi Tanamoto   Masashi Muroi   Kei-ichi Sugiyama   Nathan A. Davies   Rajeshwar P. Mookerjee   Dipok Kumar Dhar   Rajiv Jalan   
Strategies for the prevention of multiorgan dysfunction (MOD) in acetaminophen (APAP)-induced acute liver failure (ALF) are an unmet need. Our study tested the hypothesis that sterile inflammation induced by APAP in a mouse model would activate to...
PATHOGENS AND DISEASE 67(3) 199-205 2013年4月 [査読有り]
We investigated the difference in the effect of synthetic lipid A compounds on MyD88-dependent and -independent Toll-like receptor 4 (TLR4) signaling in mouse macrophage cells. At higher concentrations, Escherichia coli-type hexa-acylated lipid A ...
In Europe, semicarbazide (SEM) was detected from bottled baby foods. SEM is a thermal degradation product of azodicarbonamide which is a foaming agent for plastic gaskets on metal lids. In this paper, a determination method of SEM by the increment...
In order to set official analytical method in foods, the method of determining polysorbates(PSs) with rapid screening test by TLC and colorimetric assay were developed. PSs were extracted from processed foods with acetonitrile containing methanol....