FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 53(2) 260-264 2008年7月 [査読有り]
IRAK-4 plays an essential role in Toll-like receptor (TLR)/IL-1 receptor signaling. However, its signaling and regulation mechanisms have remained elusive. We have reported previously that stimulation of TLR2, TLR4 or TLR9, but not TLR3, leads to ...
JOURNAL OF LEUKOCYTE BIOLOGY 83(3) 702-707 2008年3月 [査読有り]
MyD88 and IL-1R- associated kinase 1 (IRAK-1) play crucial roles as adaptor molecules in signal transduction of the TLR/IL-1R superfamily, and it is known that expression of these proteins leads to the activation of NF-kappa B in a TNFR-associated...
Takahiro Ohnishi Tomohisa Yoshida Arisa Igarashi Masashi Muroi Ken-Ichi Tanamoto
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 52(2) 293-295 2008年3月 [査読有り]
Endocrine disrupting chemicals (EDCs) may potentially worsen infectious diseases because EDCs disturb human immune function by interfering with endocrine balance. To evaluate the influence of EDCs on the innate immune function of macrophages, we i...
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 51(1) 84-91 2007年10月 [査読有り]
We analysed the lipopolysaccharide (LPS)-recognition mechanism in cells expressing TLR4 and CD14 but lacking MD-2. When TLR4 and CD14 were transiently expressed in HEK293 cells, cell-surface expression of TLR4 was observed, although the expression...
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