教養教育 - 武蔵野大学教員情報 | 武蔵野大学 [MUSASHINO UNIVERSITY]

研究分野

ナノテク・材料 / 生体化学 /

学歴

-

1975年

東京大学薬学研究科薬化学

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1975年

東京大学

-

1969年

横浜国立大学工学部応用化学

-

1969年

横浜国立大学

受賞

1984年

佐藤記念国内賞

MISC

<4 567 8 >

Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using β-cyclodextrin as a mobile-phase additive.

MINAMI C DENG Y URANO F KAIYA T KOHDA K KAWAI M NAOI M

J. Chromatography B 702(1-2) 245-248 1997年11月

Substrate specificity of human O-6-methylguanine-DNA methyltransferase for O-6-benzylguanine derivatives in oligodeoxynucleotides

Terashima, I H Kawate K Sakumi M Sekiguchi K Kohda

CHEMICAL RESEARCH IN TOXICOLOGY 10(11) 1234-1239 1997年11月

To investigate the substrate specificity of human O-6-methylguanine-DNA methyltransferase (MGMT) for O-6-benzylguanine (6BG) derivatives incorporated in oligodeoxynucleotides, we prepared 25-mer lengths of sequences containing various 6BG derivati...

Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using beta-cyclodextrin as a mobile-phase additive

C Minami YL Deng F Urano T Kaiya K Kohda M Kawai M Naoi

JOURNAL OF CHROMATOGRAPHY B 702(1-2) 245-248 1997年11月

A new preparation method was devised using beta-cyclodextrin as a mobile-phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N...

An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

W Maruyama M Naoi T Kasamatsu Y Hashizume T Takahashi K Kohda P Dostert

JOURNAL OF NEUROCHEMISTRY 69(1) 322-329 1997年7月

Recently, an endogenous neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl-(R)-salsolinol], was found to elicit parkinsonism in rats with selective depletion of dopamine neurons in the substantia nigra without ne...

An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

W Maruyama M Naoi T Kasamatsu Y Hashizume T Takahashi K Kohda P Dostert

JOURNAL OF NEUROCHEMISTRY 69(1) 322-329 1997年7月

Recently, an endogenous neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl-(R)-salsolinol], was found to elicit parkinsonism in rats with selective depletion of dopamine neurons in the substantia nigra without ne...