Changsheng Wu   Koji Ichinose   Young Hae Choi   Gilles P van Wezel   
Chembiochem : a European journal of chemical biology 18(14) 1428-1434 2017年7月 [査読有り]
The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC) o...
Changsheng Wu   Chao Du   Koji Ichinose   Young Hae Choi   Gilles P. van Wezel   
JOURNAL OF NATURAL PRODUCTS 80(2) 269-277 2017年2月 [査読有り]
Mining of microbial genomes has revealed that actinomycetes harbor far more biosynthetic potential for bioactive natural products than anticipated. Activation of (cryptic) biosynthetic gene clusters and identification of the corresponding metaboli...
Type II polyketide synthases iteratively generate a nascent polyketide thioester of the acyl carrier protein (ACP)
this is structurally modified to produce an ACP-free intermediate towards the final metabolite. However, the timing of ACP off-load...