JOURNAL OF ANTIBIOTICS 68(7) 481-483 2015年7月 [査読有り]
A new shunt product was isolated from a actVA4 mutant strain of Streptomyces coeliclor A3(2). Its structure was elucidated based on stectrocipic data. Its biosynthetic implication in the actinorhodin pawathway was also presented.
Jacob Gubbens   Hua Zhu   Genevieve Girard   Lijiang Song   Bogdan I. Florea   Philip Aston   Koji Ichinose   Dmitri V. Filippov   Young H. Choi   Herman S. Overkleeft   Gregory L. Challis   Gilles P. van Wezel   
CHEMISTRY & BIOLOGY 21(6) 707-718 2014年6月 [査読有り]
Information on gene clusters for natural product biosynthesis is accumulating rapidly because of the current boom of available genome sequencing data. However, linking a natural product to a specific gene cluster remains challenging. Here, we pres...
Phytomedicine : international journal of phytotherapy and phytopharmacology 21(6) 800-6 2014年5月 [査読有り]
We previously demonstrated that ethyl acetate extracts of Kaempferia parviflora Wall. Ex Baker (KPE) improve insulin resistance in TSOD mice and showed that its components induce differentiation and adipogenesis in 3T3-L1 preadipocytes. The presen...
Journal of natural medicines 68(2) 442-7 2014年4月 [査読有り]
Garlic (Allium sativum L.) has been used worldwide as a food and for medicinal purposes since early times. Garlic cultivars exhibit considerable morphological diversity despite the fact that they are mostly sterile and are grown only by vegetative...
Actinorhodin (ACT) produced by Streptomyces coelicolor A3(2) belongs to the benzoisochromanequinone (BIQ) class of antibiotics. ActVA-ORF5, a flavin-dependent monooxygenase (FMO) essential for ACT biosynthesis, forms a two-component enzyme system ...