The American journal of pathology 188(6) 1328-1333 2018年6月 [査読有り]
Our aim was to develop a serodiagnostic marker for lung cancer. Monoclonal antibodies were generated, and one antibody designated as KU-Lu-1, recognizing cytoskeleton-associated protein 4 (CKAP4), was studied further. To evaluate the utility of KU...
Pathology international 68(4) 232-240 2018年4月 [査読有り]
We established the KU-Lu-8 monoclonal antibody (MoAb) using a lung cancer cell line as an antigen and a random immunization method. The KU-Lu-8 MoAb recognizes basigin (BSG), which is a transmembrane-type glycoprotein that is strongly expressed on...
Ciliogenesis is generally inhibited in dividing cells, however, it has been unclear which signaling cascades regulate the phenomenon. Here, we report that epidermal growth factor receptor (EGFR) kinase suppresses ciliogenesis by directly phosphory...
Oncogenic mutations of RAS genes, found in about 30% of human cancers, are considered to play important roles in cancer development. However, oncogenic RAS can also induce senescence in mouse and human normal fibroblasts. In some cell lines, oncog...
Shinya Ito   Koji Ogawa   Koh Takeuchi   Motoki Takagi   Masahito Yoshida   Takatsugu Hirokawa   Shoshiro Hirayama   Kazuo Shin-ya   Ichio Shimada   Takayuki Doi   Naoki Goshima   Tohru Natsume   Kazuhiro Nagata   
JOURNAL OF BIOLOGICAL CHEMISTRY 292(49) 20076-20085 2017年12月 [査読有り]
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promisi...