The asteltoxin-producing fungus Emericella variecolor IFM42010 possesses 22 highly-reducing polyketide synthase (HR-PKS) genes. Of these, an HR-PKS with a methyltransferase domain but lacking an enoylreductase domain could be involved in the biosy...
Ichinose K   Hashimoto M   Taguchi T   Ishikawa K   Mori R   Hotta A   Watari S   Katakawa K   Kumamoto T   Okamoto S   
Chembiochem : a European journal of chemical biology 21(5) 623-627 2019年9月 [査読有り]
CsyB from Aspergillus oryzae is a novel type III polyketide synthase that catalyzes the formation of csypyrone B1 [4-(3-acetyl-4-hydroxy-2-oxo-2H-pyran-6- yl)butyric acid] from fatty acyl-CoA, malonyl-CoA and acetoacetyl-CoA. Recombinant CsyB expr...
Pamamycin (PM, 1) is an aerial mycelium inducer isolated from Streptomyces alboniger. It is a unique sixteen-membered macrodiolide with a dimethylamino group-bearing side chain and dimethylamino group of PM is indispensable for the activity. Feedi...