Current Medicinal Chemistry: Cardiovascular and Hematological Agents 2(3) 257-265 2004年7月 [査読有り]
Prostaglandin I2 (PGI2, prostacyclin), an eicosanoid of the cyclooxygenase pathway, causes relaxation of vascular smooth muscle in most blood vessels and inhibits platelet aggregation. PGI2 and its stable analogues activate a specific cell-surface...
EUROPEAN JOURNAL OF PHARMACOLOGY 492(1) 65-70 2004年5月 [査読有り]
The role of cAMP in the beta(2)-adrenoceptor-mediated relaxation in response to salbutamol was examined in guinea pig tracheal smooth muscle. The concentration-dependent salbutamol-induced relaxation,was antagonized in a competitive fashion by a b...
Journal of Smooth Muscle Research 40(2) 43-52 2004年4月 [査読有り]
The possible functional coupling between β1-adrenoceptor and MaxiK channels which results in smooth muscle relaxation was examined in the guinea-pig esophageal muscularis mucosae. Isoprenaline-elicited relaxation of esophageal smooth muscle was co...
Autonomic and Autacoid Pharmacology 24(2) 37-43 2004年4月 [査読有り]
1 The present study was carried out to pharmacologically identify the β-adrenoceptor subtype that mediates isoprenaline-elicited relaxation in the isolated guinea-pig tracheal smooth muscle, to answer the question whether it is β1 or β2-subtype? 2...