Journal of Smooth Muscle Research 39(6) 205-219 2003年12月 [査読有り]
We examined the contribution of large-conductance, Ca 2+-sensitive K+ (MaxiK) channel to β 2-adrenoceptor-activated relaxation to isoprenaline in guinea-pig tracheal smooth muscle focusing on the role for cAMP in the coupling between β2-adrenocept...
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 368(5) 437-441 2003年11月 [査読有り]
Cyclic AMP is a key molecule in the regulation of airway smooth muscle tone. Increased cyclic AMP leads to relaxation of this smooth muscle and its inhibition results in the muscle contraction. A constitutive role for cyclic AMP in the contraction...
MaxiK channel, the large conductance Ca2+-sensitive K + channel, is expressed abundantly in vascular smooth muscles and plays a key role in the tuning of their excitability and contractility. The present study was carried out to elucidate the cont...
Journal of Smooth Muscle Research 38(4-5) 87-99 2002年10月 [査読有り]
Isoprenaline is known to produce vascular relaxation through activation of β-adrenoceptors. In recent years, β-adrenoceptor-activated vascular relaxation has been the focus of pharmacological study in terms of both the receptor subtypes and the in...