NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 363(3) 344-352 2001年3月 [査読有り]
The vasorelaxant profile of a novel azulene-1-carboxamidine derivative, HNS-32 [N-1,N-1-dimethyl-N-2-(2-pyridylmethyl)-5-isopropyl-3,8-dimethyl-azulene-1-carboxammidine, CAS 186086-10-2], was investigated in the isolated rabbit aorta precontracted...
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 362(2) 160-168 2000年8月 [査読有り]
Noradrenaline (NA) produces sustained contractions in conduit arteries such as aorta isolated from various animal species. In guinea-pig aorta, NA-produced sustained contraction is largely dependent upon the influx of extracellular Ca2+, but is re...
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM 34(3) 159-165 2000年3月 [査読有り]
The role of L-type Ca2+ channels in the relaxation to nitric oxide (NO)-mediated MaxiK(Ca) channel activation was examined in guinea pig aorta. Acetylcholine (ACh) produced an endothelium-dependent relaxation of guinea pig aorta precontracted with...
Pharmacy and Pharmacology Communications 6(5) 195-199 2000年 [査読有り]
Vasorelaxant substances responsible for endothelium-dependent relaxation of pig coronary artery in response to noradrenaline have been investigated pharmacologically. Noradrenaline relaxed pig coronary artery in an endothelium- and concentration-d...