Pharmacy and Pharmacology Communications 6(5) 195-199 2000年 [査読有り]
Vasorelaxant substances responsible for endothelium-dependent relaxation of pig coronary artery in response to noradrenaline have been investigated pharmacologically. Noradrenaline relaxed pig coronary artery in an endothelium- and concentration-d...
Pharmacy and Pharmacology Communications 6(9) 397-404 2000年 [査読有り]
HNS-32 (N1,N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3,8-dimethylazulene-1-car boxamidine) (CAS 186086-10-2) is a newly synthesized compound with an azulene structure within the molecule. The coronary relaxant action of HNS-32 was investigated ...
EUROPEAN JOURNAL OF PHARMACOLOGY 366(2-3) R9-R10 1999年2月 [査読有り]
Possible involvement of endothelium was examined in the vasorelaxation of rat aorta in response to NIP-121 ((+)-7,8-dihydro-6,6-dimethyl-7-hyroxy-8-(2-oxo- 1-piperidinyl)-6H-pyrano[2,3-f]benz-2,1,3-oxadiazole), an ATP-sensitive K+ (K-ATP) channel ...