A. Shiirevnyamba T. Takahashi H. Shan H. Ogawa S. Yano H. Kanayama K. Izumi H. Uehara
BRITISH JOURNAL OF CANCER 104(3) 505-513 2011年2月 [査読有り]
BACKGROUND: The interaction between prostate cancer cells and osteoblasts is critical for the development of bone metastasis. Metastatic cancer cells may physically contact osteoblasts in the bone microenvironment; however, the biological signific...
Ezar Hafez Tetsuyuki Takahashi Hirohisa Ogawa Makoto Sato Tokiko Nakai Chie Takasu Hisanori Uehara Keisuke Izumi
Journal of Toxicologic Pathology 24(4) 187-193 2011年 [査読有り]
Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of typ...
Fuminori Aki Yoshimi Bando Tetsuyuki Takahashi Hisanori Uehara Satoshi Numoto Sueyoshi Ito Mitsunori Sasa Keisuke Izumi
ONCOLOGY LETTERS 1(6) 981-987 2010年11月 [査読有り]
Nucleic acid-metabolizing enzymes, such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and rotate phosphoribosyl transferase (OPRT), have attracted attention as candidates for response determinant...
Journal of Medical Investigation 56(3-4) 93-98 2009年 [査読有り]
The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examin...
Tetsuyuki Takahashi Hisanori Uehara Yoshimi Bando Keisuke Izumi
MOLECULAR CANCER THERAPEUTICS 7(9) 2807-2816 2008年9月 [査読有り]
Prostaglandin E-2 (PGE(2)) plays a key role in osteolytic bone metastasis as well as roles in inflammation, cell growth, and tumor development. PGE2 exerts its effects by binding and activating E-prostanoid receptor (EP). In this study, we propose...
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