JOURNAL OF IMMUNOLOGY 180(10) 6997-7008 2008年5月 [査読有り]
A mutant strain with defective thymic selection of the Long-Evans Cinnamon (LEC) rat was found to spontaneously develop inflammatory bowel disease (IBD)-like colitis. The secretion of Th1-type cytokines including IFN-gamma and IL-2 from T cells of...
Cellular damage induced by chronic inflammation is a well known cause of colon carcinogenesis. Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to prostanoids, is known to play an important role in inflammation. Herbal flavonoid...
T Takahashi N Takasuka M Iigo M Baba H Nishino H Tsuda T Okuyama
CANCER SCIENCE 95(5) 448-453 2004年5月 [査読有り]
Isoliquiritigenin (ILTG), a flavonoid group compound, exists in some foodstuffs and herbal medicines such as licorice (Glycyrrhiza uralensis Fisher). Previously, we showed that ILTG can suppress azoxymethane (AOM)-induced colon carcinogenesis in d...
Isoliquiritigenin is a natural pigment with the simple chalcone structure, 4,2',4'-trihydroxychalcone. The effect of this compound on azoxymethane (AOM)-induced colonic aberrant crypt focus and tumor formation in ddY mice was examined. Administrat...
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