JOURNAL OF CELL BIOLOGY 216(6) 1731-1743 2017年6月 [査読有り]
Mammalian endoplasmic reticulum (ER) exit sites export a variety of cargo molecules including oversized cargoes such as collagens. However, the mechanisms of their assembly and organization are not fully understood. TAN GO1L is characterized as a ...
MOLECULAR BIOLOGY OF THE CELL 27(17) 2688-2696 2016年9月 [査読有り]
Collagens synthesized within the endoplasmic reticulum (ER) are too large to fit in conventional COPII-coated transport vesicles; thus their export from the ER requires specialized factors. TANGO1 (L) is an integral membrane protein that binds to ...
MOLECULAR BIOLOGY OF THE CELL 27(13) 2008-2013 2016年7月 [査読有り]
Two independent functions of cTAGE5 have been reported in collagen VII export from the endoplasmic reticulum (ER). cTAGE5 not only forms a cargo receptor complex with TANGO1, but it also acts as a scaffold to recruit Sec12, a guanine-nucleotide ex...
Adult T-cell leukemia/lymphoma (ATLL) is a distinct form of peripheral T-cell lymphoma with poor prognosis, which is caused by the human T-lymphotropic virus type 1 (HTLV-1). In contrast to the unequivocal importance of HTLV-1 infection in the pat...
CELLULAR AND MOLECULAR LIFE SCIENCES 72(19) 3709-3720 2015年10月 [査読有り]
Cargo proteins exported from the endoplasmic reticulum to the Golgi apparatus are typically transported in coat protein complex II (COPII)-coated vesicles of 60-90 nm diameter. Several cargo molecules including collagens and chylomicrons form stru...
JOURNAL OF BIOLOGICAL CHEMISTRY 268(35) 26067-26070 1993年12月
We recently identified four isoforms of bovine prostaglandin E receptor EP3 subtype, which are coupled to different signaling pathways; EP3A is coupled to inhibition of adenylate cyclase, while EP3B and EP3C are coupled to its stimulation and EP3D...