T IIRI   Y OHOKA   M UI   T KATADA   
JOURNAL OF BIOLOGICAL CHEMISTRY 267(2) 1020-1026 1992年1月 [査読有り]
The alpha-subunit of G(i-2), in addition to that of G(s) (GTP-binding proteins involved in adenylate cyclase inhibition and stimulation, respectively) was ADP-ribosylated by cholera toxin in HL-60 cell membranes when a chemotactic receptor was sti...
T IIRI   Y OHOKA   M UI   T KATADA   
EUROPEAN JOURNAL OF BIOCHEMISTRY 202(2) 635-641 1991年12月 [査読有り]
The alpha-subunits of G(i) (G(i)alpha) and G(s) (guanine-nucleotide-binding proteins involved in adenylate cyclase inhibition and stimulation, respectively) was ADP-ribosylated by cholera toxin in differentiated HL-60 cell membranes upon stimulati...
H ITO   T SUGIMOTO   KOBAYASHI, I   K TAKAHASHI   T KATADA   M UI   Y KURACHI   
JOURNAL OF GENERAL PHYSIOLOGY 98(3) 517-533 1991年9月 [査読有り]
Using the patch clamp technique, we examined the agonist-free, basal interaction between the muscarinic acetylcholine (m-ACh) receptor and the G protein (G(K))-gated muscarinic K+ channel (I(K.ACh)), and the modification of this interaction by ACh...
JOURNAL OF BIOLOGICAL CHEMISTRY 266(16) 10062-10065 1991年6月 [査読有り]
A novel enzyme activity was found in bovine brain cytosol that transfers the ADP-ribosyl moiety of NAD to proteins with M(r) values of 22,000 and 25,000. The substrates were the same GTP-binding proteins serving as the substrate of an ADP-ribosylt...
CHEMISTRY AND PHYSICS OF LIPIDS 98(1-2) 79-86 1999年4月
Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in a variety of receptor-stimulated cell responses. Stimulation of receptors possessing (or coupling to) protein-tyrosine kinase activates heterodimeric PI 3-kinases, whi...