Bulat I. Khayrutdinov Won Jin Bae Young Mi Yun Jie Hye Lee Takashi Tsuyama Jung Joo Kim Eunha Hwang Kyoung-Seok Ryu Hae-Kap Cheong Chaejoon Cheong Jung-Soon Ko Takemi Enomoto P. Andrew Karplus Peter Guentert Shusuke Tada Young Ho Jeon Yunje Cho
PROTEIN SCIENCE 18(11) 2252-2264 2009年11月
In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. The C-terminal domain of mouse Cdt1 (mCdt1C), the most conserved region in Cdt1, is essential for licensing and directly int...
The surfaces of core histones in nucleosome are exposed as required for factor recognition, or buried for histone-DNA and histone-histone interactions. To understand the mechanisms by which nucleosome structure and function are coordinately altere...
The surfaces of core histones in nucleosome are exposed as required for factor recognition, or buried for histone-DNA and histone-histone interactions. To understand the mechanisms by which nucleosome structure and function are coordinately altere...
The antibiotic heliquinomycin, which inhibits cellular DNA replication at a half-maximal inhibitory concentration (IC(50)) of 1.4-4 mu m, was found to inhibit the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex at...
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutan...
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