The pre-spliceosomal complex involves interactions between U1 and U2 snRNPs, where a ubiquitin-like domain (ULD) of SF3A1, a component of U2 snRNP, binds to the stem-loop 4 (SL4; the UUCG tetraloop) of U1 snRNA in U1 snRNP. Here, we repo...
<title>Abstract</title>
The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation...
Sato A   Muto Y   Kuwasako K   Shirouzu M   Terada T   Kigawa T   Inoue M   Nagata T   Suzuki S   Someya T   Tsuda K   Takahashi S   Sugano S   Yokoyama S   
Kuwasako K   Muto Y   Shirouzu M   Terada T   Kigawa T   Inoue M   Valcarcel J   Yokoyama S