研究者氏名	渡邊幸子
	ワタナベサチコ
URL	https://kaken.nii.ac.jp/ja/search/?qm=80770619
所属	武蔵野大学
部署	薬学部薬学科
職名	助教
学位	理学博士(北里大学)
科研費研究者番号	80770619
J-Global ID	201601011762460322

研究分野

ライフサイエンス / 免疫学 /

経歴

2021年4月

現在

武蔵野大学薬学部薬学科助教

2016年3月

2019年9月

自治医科大学炎症・免疫研究部助教

2016年2月

京都大学医学研究科

学歴

2008年4月

2013年3月

北里大学大学院理学研究科

論文

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Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.

Fumiya Anzai Sachiko Watanabe Hiroaki Kimura Ryo Kamata Tadayoshi Karasawa Takanori Komada Jun Nakamura Noriko Nagi-Miura Naohito Ohno Yasuchika Takeishi Masafumi Takahashi

Journal of molecular and cellular cardiology 138 185-196 2020年1月 [査読有り]

Kawasaki disease (KD) is a systemic febrile syndrome during childhood that is characterized by coronary arteritis. The etiopathogenesis of KD remains to be elucidated. NLRP3 inflammasome is a large multiprotein complex that plays a key role in IL-...

Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.

Homare Ito Ai Sadatomo Yoshiyuki Inoue Naoya Yamada Emi Aizawa Erika Hishida Ryo Kamata Tadayoshi Karasawa Hiroaki Kimura Sachiko Watanabe Takanori Komada Hisanaga Horie Joji Kitayama Naohiro Sata Masafumi Takahashi

Biochemical and biophysical research communications 519(1) 15-22 2019年10月 [査読有り]

BACKGROUND: Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. However, the underlying mechanism is not yet fully understood. Toll-like receptor 5 (TLR5) is highly ex...

Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis.

Erika Hishida Homare Ito Takanori Komada Tadayoshi Karasawa Hiroaki Kimura Sachiko Watanabe Ryo Kamata Emi Aizawa Tadashi Kasahara Yoshiyuki Morishita Tetsu Akimoto Daisuke Nagata Masafumi Takahashi

Scientific reports 9(1) 10363-10363 2019年7月 [査読有り]

Long-term peritoneal dialysis (PD) therapy leads to peritoneal inflammation and fibrosis. However, the mechanism underlying PD-related peritoneal inflammation and fibrosis remains unclear. NLRP3 inflammasome regulates the caspase-1-dependent relea...

Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration-Induced Acute Lung Injury.

Yoshiko Mizushina Tadayoshi Karasawa Kenichi Aizawa Hiroaki Kimura Sachiko Watanabe Ryo Kamata Takanori Komada Naoko Mato Tadashi Kasahara Shinichiro Koyama Masashi Bando Koichi Hagiwara Masafumi Takahashi

Journal of immunology (Baltimore, Md. : 1950) 203(1) 236-246 2019年7月 [査読有り]

Inflammation plays a pivotal role in the pathophysiology of gastric aspiration-induced acute lung injury (ALI). However, its mechanism remains unclear. In this study, we investigated the role of NLRP3 inflammasome-driven IL-1β production in a mous...

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.

Jun Nakamura Sachiko Watanabe Hiroaki Kimura Motoi Kobayashi Tadayoshi Karasawa Ryo Kamata Fumitake Usui-Kawanishi Ai Sadatomo Hiroaki Mizukami Noriko Nagi-Miura Naohito Ohno Tadashi Kasahara Seiji Minota Masafumi Takahashi

Scientific reports 8(1) 7601-7601 2018年5月 [査読有り]

Kawasaki disease (KD), which is the leading cause of pediatric heart disease, is characterized by coronary vasculitis and subsequent aneurysm formation. Although intravenous immunoglobulin therapy is effective for reducing aneurysm formation, a ce...