研究者氏名	渡邊幸子
	ワタナベサチコ
URL	https://kaken.nii.ac.jp/ja/search/?qm=80770619
所属	武蔵野大学
部署	薬学部薬学科
職名	助教
学位	理学博士(北里大学)
科研費研究者番号	80770619
J-Global ID	201601011762460322

研究分野

ライフサイエンス / 免疫学 /

経歴

2021年4月

現在

武蔵野大学薬学部薬学科助教

2016年3月

2019年9月

自治医科大学炎症・免疫研究部助教

2016年2月

京都大学医学研究科

学歴

2008年4月

2013年3月

北里大学大学院理学研究科

論文

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Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.

Tadayoshi Karasawa Akira Kawashima Fumitake Usui-Kawanishi Sachiko Watanabe Hiroaki Kimura Ryo Kamata Koumei Shirasuna Yutaro Koyama Ayana Sato-Tomita Takashi Matsuzaka Hiroshi Tomoda Sam-Yong Park Naoya Shibayama Hitoshi Shimano Tadashi Kasahara Masafumi Takahashi

Arteriosclerosis, thrombosis, and vascular biology 38(4) 744-756 2018年4月 [査読有り]

OBJECTIVE: Inflammation provoked by the imbalance of fatty acid composition, such as excess saturated fatty acids (SFAs), is implicated in the development of metabolic diseases. Recent investigations suggest the possible role of the NLRP3 (nucleot...

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.

Akira Kawashima Tadayoshi Karasawa Kenji Tago Hiroaki Kimura Ryo Kamata Fumitake Usui-Kawanishi Sachiko Watanabe Satoshi Ohta Megumi Funakoshi-Tago Ken Yanagisawa Tadashi Kasahara Koichi Suzuki Masafumi Takahashi

Journal of immunology (Baltimore, Md. : 1950) 199(10) 3614-3622 2017年11月 [査読有り]

The nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and subsequent IL-1β maturation, and is implicated in inflammatory diseases...

Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.

Ai Sadatomo Yoshiyuki Inoue Homare Ito Tadayoshi Karasawa Hiroaki Kimura Sachiko Watanabe Yoshiko Mizushina Jun Nakamura Ryo Kamata Tadashi Kasahara Hisanaga Horie Naohiro Sata Masafumi Takahashi

Journal of immunology (Baltimore, Md. : 1950) 199(9) 3306-3315 2017年11月 [査読有り]

Accumulating evidence suggests that IL-1β plays a pivotal role in the pathophysiology of hepatic ischemia-reperfusion (I/R) injury; however, the mechanism by which I/R triggers IL-1β production in the liver remains unclear. Recent data have shown ...

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.

Motoi Kobayashi Fumitake Usui-Kawanishi Tadayoshi Karasawa Hiroaki Kimura Sachiko Watanabe Nathan Mise Fujio Kayama Tadashi Kasahara Naoyuki Hasebe Masafumi Takahashi

PloS one 12(5) e0176676 2017年 [査読有り]

Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatmen...

Involvement of aquaporin-3 in epidermal growth factor receptor signaling via hydrogen peroxide transport in cancer cells.

Mariko Hara-Chikuma Sachiko Watanabe Hiroki Satooka

Biochemical and biophysical research communications 471(4) 603-9 2016年3月 [査読有り]

Aquaporin 3 (AQP3), a water/glycerol channel protein, is capable of transporting hydrogen peroxide (H2O2). Here, we show that AQP3-mediated intracellular H2O2 is involved in epidermal growth factor (EGF)-induced cell signaling and its dependent ce...