JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 58 2020年8月
Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation or residual crystallinity formation. This caveat may be addressed by optimizing for-mulations and manufacturing...
Drug development and industrial pharmacy 46(2) 179-187 2020年2月 [査読有り]
Spray freeze drying (SFD) produces suitable particles for the pharmaceutical formulation of dry powders used in dry powder inhalers (DPIs). However, SFD particles have large specific surface area and are partially made up of amorphous solids; this...
In this study, we established a robust feed-forward control model for the tableting process by partial least squares regression using the near-infrared (NIR) spectra and physical attributes of the granules to be compressed. The NIR spectra of gran...
Formulation of a cocrystal into a solid pharmaceutical dosage form entails numerous processing steps during which there is risk of dissociation. In an effort to reduce the number of unit operations, we have attempted the in situ formation of an in...
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 53 2019年10月
In order to investigate the effect of phytic acid on the improvement of disintegration time (DT) of gelatin-based film sheets, gelatin film sheets and succinylated gelatin film sheets with various concentrations of phytic acid were dipped and stor...
This project is the renovation of the lighting of a historic commercial building. The Orchard Road corner lot is a prime location for this fine landmark, a massive, but stately architectural structure with red eaves and Chinese inspired motifs. Ou...