Journal of Drug Delivery Science and Technology 46 111-121 2018年8月 [査読有り]
In order to establish a pharmaceutical manufacturing process control system based on a Quality-by-Design concept, the pharmaceutical properties of tablets during the tablet-coating process were monitored in real time and predicted using values rec...
Drug Development and Industrial Pharmacy 44(5) 713-722 2018年5月 [査読有り]
We developed a method for the optimization of dissolution properties of solid oral dosage forms manufacturing using high shear wet granulation (HSWG) by using near-infrared spectroscopy (NIRS) with chemometrics in small-scale experiments. The chan...
Journal of Drug Delivery Science and Technology 44 1-7 2018年4月 [査読有り]
Ulinastatin (UTI) is a trypsin inhibitor derived from human urine. UTI has inhibitory activities against many enzymes, and is clinically effective and safe for the treatment of acute pancreatitis. Administration of UTI into the vagina is an effect...
International Journal of Pharmaceutics 539(1-2) 31-38 2018年3月 [査読有り]
The relationships between the physicochemical properties of milled starch and drug release from tablets were investigated quantitatively using a drug release kinetic method and X-ray computed tomography (XCT). The samples were prepared from raw β-...
This project is the renovation of the lighting of a historic commercial building. The Orchard Road corner lot is a prime location for this fine landmark, a massive, but stately architectural structure with red eaves and Chinese inspired motifs. Ou...