Non-destructive and quantitative investigation of density distribution of round tablets was the objectives of this study. The density distribution of round tablets was observed using X-ray computed tomography (X-ray CT). The distribution images we...
INTERNATIONAL JOURNAL OF PHARMACEUTICS 511(2) 757-764 2016年9月 [査読有り]
Magnesium stearate (Mg-St) is a common lubricant used for solid pharmaceutical formulations and is known for its property to cause delay of tablet dissolution. In this study, the mechanism underlying the delay caused by Mg-St was investigated with...
CHEMICAL PHYSICS LETTERS 661 114-118 2016年9月 [査読有り]
In this study, formations of pi-pi and CH-pi interactions in the crystallization of amorphous indomethacin (IMC) were investigated by simultaneous Raman spectroscopy and X-ray diffraction (XRD) measurements. The activation energy obtained from the...
Many pharmaceutical bulk powders are known to have various solid states, such as polymorphic forms, solvates, and amorphous forms. The amorphous form is known to be recrystallized by absorbing various solvent vapors depending on the chemical prope...
Yusuke Hattori   Hiroe Mori   Joshua Chou   Makoto Otsuka   
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 42(4) 595-601 2016年4月 [査読有り]
In this study, in order to control zinc (Zn)-release from calcium phosphate (CaP), the crystalline forms of CaP-containing Zn were modified by wet ball milling and/or heat treatment. The CaP (CaO:CaHPO4:ZnO=7:20:3, molar ratio) was ground in a bal...
This project is the renovation of the lighting of a historic commercial building. The Orchard Road corner lot is a prime location for this fine landmark, a massive, but stately architectural structure with red eaves and Chinese inspired motifs. Ou...