Mixing processes are important for making high-quality pharmaceutical formulations and are related to dissolution and chemical stability in pharmaceutical manufacturing. The resonant acoustic (R) mixing (RAM) technology is a blending method, and i...
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 42(11) 1851-1856 2016年 [査読有り]
The objectives of this study were to characterize and investigate the differences in amorphous states of gatifloxacin. We prepared two types of gatifloxacin amorphous solids coded as M and MQ using milling and melt-quenching methods, respectively....
Yusuke Hattori   Maiko Sato   Makoto Otsuka   
JOURNAL OF PHARMACY AND PHARMACOLOGY 67(11) 1512-1518 2015年11月 [査読有り]
ObjectivesObjectives of this study are investigating the initial dissolution kinetics of the cocrystal of carbamazepine (CBZ) with nicotinamide (NIC) and understanding its initial dissolution process.
MethodsCocrystal solids of CBZ with NIC were p...
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 41(3) 515-521 2015年3月 [査読有り]
The objective of this research was to quantify the alpha-mangostin content in mangosteen pericarp (MP) ointment as a colloidal dispersion using near-infrared (NIR) spectroscopy. Various concentrations of MP (IP and EP) ointments containing both in...
JOURNAL OF NEAR INFRARED SPECTROSCOPY 23(3) 189-196 2015年 [査読有り]
Starch is a natural polymeric with high chemical stability and no toxicity, so it is used widely as an additive in pharmaceutical manufacturing and the food industry. In this study, the effect of heat treatment on the controlled theophylline (TH) ...
This project is the renovation of the lighting of a historic commercial building. The Orchard Road corner lot is a prime location for this fine landmark, a massive, but stately architectural structure with red eaves and Chinese inspired motifs. Ou...