Advances in experimental medicine and biology 1444 97-108 2024年
Nucleic acid (NA)-sensing Toll-like receptors (TLRs) reside in the endosomal compartment of innate immune cells, such as macrophages and dendritic cells. NAs transported to the endosomal compartment are degraded by DNases and RNases. Degradation p...
Eosinophils are typical effector cells associated with type 2 immune responses and play key roles in the pathogenesis of allergic diseases. These cells are activated by various stimuli, such as cytokines, chemokines, and growth factors,...
Gang Liu Tatt Jhong Haw Malcolm R Starkey Ashleigh M Philp Stelios Pavlidis Christina Nalkurthi Prema M Nair Henry M Gomez Irwan Hanish Alan Cy Hsu Elinor Hortle Sophie Pickles Joselyn Rojas-Quintero Raul San Jose Estepar Jacqueline E Marshall Richard Y Kim Adam M Collison Joerg Mattes Sobia Idrees Alen Faiz Nicole G Hansbro Ryutaro Fukui Yusuke Murakami Hong Sheng Cheng Nguan Soon Tan Sanjay H Chotirmall Jay C Horvat Paul S Foster Brian Gg Oliver Francesca Polverino Antonio Ieni Francesco Monaco Gaetano Caramori Sukhwinder S Sohal Ken R Bracke Peter A Wark Ian M Adcock Kensuke Miyake Don D Sin Philip M Hansbro
Nature communications 14(1) 7349-7349 2023年11月
Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the seve...
Toll-like receptors (TLRs) respond to pathogen constituents, such as microbial lipids and nucleic acids (NAs). TLRs recognize NAs in endosomal compartments. Structural and functional studies have shown that recognition of NAs by TLRs depends on NA...
Am a L. Gavin Deli Huang Tanya R. Blane Therese C. Thinnes Yusuke Murakami Ryutaro Fukui Kensuke Miyake David Nemazee
Nature Communications 12(1) 5874-5874 2021年12月
<jats:title>Abstract</jats:title><jats:p>Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. M...
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