Advances in experimental medicine and biology 1444 97-108 2024年
Nucleic acid (NA)-sensing Toll-like receptors (TLRs) reside in the endosomal compartment of innate immune cells, such as macrophages and dendritic cells. NAs transported to the endosomal compartment are degraded by DNases and RNases. Degradation p...
Eosinophils are typical effector cells associated with type 2 immune responses and play key roles in the pathogenesis of allergic diseases. These cells are activated by various stimuli, such as cytokines, chemokines, and growth factors,...
Gang Liu   Tatt Jhong Haw   Malcolm R Starkey   Ashleigh M Philp   Stelios Pavlidis   Christina Nalkurthi   Prema M Nair   Henry M Gomez   Irwan Hanish   Alan Cy Hsu   Elinor Hortle   Sophie Pickles   Joselyn Rojas-Quintero   Raul San Jose Estepar   Jacqueline E Marshall   Richard Y Kim   Adam M Collison   Joerg Mattes   Sobia Idrees   Alen Faiz   Nicole G Hansbro   Ryutaro Fukui   Yusuke Murakami   Hong Sheng Cheng   Nguan Soon Tan   Sanjay H Chotirmall   Jay C Horvat   Paul S Foster   Brian Gg Oliver   Francesca Polverino   Antonio Ieni   Francesco Monaco   Gaetano Caramori   Sukhwinder S Sohal   Ken R Bracke   Peter A Wark   Ian M Adcock   Kensuke Miyake   Don D Sin   Philip M Hansbro   
Nature communications 14(1) 7349-7349 2023年11月
Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the seve...
Toll-like receptors (TLRs) respond to pathogen constituents, such as microbial lipids and nucleic acids (NAs). TLRs recognize NAs in endosomal compartments. Structural and functional studies have shown that recognition of NAs by TLRs depends on NA...
Am   a L. Gavin   Deli Huang   Tanya R. Blane   Therese C. Thinnes   Yusuke Murakami   Ryutaro Fukui   Kensuke Miyake   David Nemazee   
Nature Communications 12(1) 5874-5874 2021年12月
<jats:title>Abstract</jats:title><jats:p>Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. M...