CELL STRUCTURE AND FUNCTION 33(2) 163-169 2008年 [査読有り]
miR-1, miR-133a, and miR-206 are muscle-specific microRNAs expressed in skeletal muscles and have been shown to contribute to muscle development. To gain insight into the pathophysiological roles of these three microRNAs in dystrophin-deficient mu...
K. Yuasa M. Yoshimura N. Urasawa S. Ohshima J. M. Howell A. Nakamura T. Hijikata Y. Miyagoe-Suzuki S. Takeda
GENE THERAPY 14(17) 1249-1260 2007年9月 [査読有り]
Using murine models, we have previously demonstrated that recombinant adeno-associated virus (rAAV)-mediated microdystrophin gene transfer is a promising approach to treatment of Duchenne muscular dystrophy (DMD). To examine further therapeutic ef...
Background: Matrix metalloproteinases ( MMPs) are key regulatory molecules in the formation, remodeling and degradation of all extracellular matrix (ECM) components in both physiological and pathological processes in various tissues. The aim of th...
Background: Cardiac mortality in Duchenne muscular dystrophy (DMD) has recently become important, because risk of respiratory failure has been reduced due to widespread use of the respirator. The cardiac involvement is characterized by distinctive...
Canine X-linked muscular dystrophy (CXMD), which was found in a colony of golden retriever, is caused by a mutation in the dystrophin gene and it is a useful model of Duchenne muscular dystrophy (DMD). To investigate the pathogenesis and to develo...
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薬科学研究科