M Yoshimura M Sakamoto M Ikemoto Y Mochizuki K Yuasa Y Miyagoe-Suzuki S Takeda
MOLECULAR THERAPY 10(5) 821-828 2004年11月 [査読有り]
Duchenne muscular dystrophy (DMD) is a lethal disorder of skeletal muscle caused by mutations in the dystrophin gene. Adeno-associated virus (AAV) vector-mediated gene therapy is a promising approach to the disease. Although a rod-truncated microd...
H Hara A Monsonego K Yuasa K Adachi M Xiao S Takeda K Takahashi HL Weiner T Tabira
JOURNAL OF ALZHEIMERS DISEASE 6(5) 483-488 2004年10月 [査読有り]
A new oral vaccine for Alzheimer's disease was developed using recombinant adeno-associated virus vector carrying Abeta cDNA (AAV/Abeta). Oral administration of the vaccine without adjuvant induced the expression and secretion of Abeta1-43 or Abet...
Y Shimatsu K Katagiri T Furuta M Nakura Y Tanioka K Yuasa M Tomohiro JN Kornegay Nonaka, I S Takeda
EXPERIMENTAL ANIMALS 52(2) 93-97 2003年4月 [査読有り]
The purpose of this study was to develop a strain of canine X-linked muscular dystrophy (CXMD), a model of Duchenne muscular dystrophy, in Japan. A female beagle was artificially inseminated with frozen-thawed spermatozoa derived from an affected ...
K Yuasa M Sakamoto Y Miyagoe-Suzuki A Tanouchi H Yamamoto J Li JS Chamberlain Xiao, X S Takeda
GENE THERAPY 9(23) 1576-1588 2002年12月 [査読有り]
Duchenne muscular dystrophy (DMD) is an X-linked, lethal muscular disorder caused by a defect in the DMD gene. AA V vector-mediated micro-dystrophin cDNA transfer is an attractive approach to treatment of DMD. To establish effective gene transfer ...
Y Hosaka T Yokota Y Miyagoe-Suzuki K Yuasa M Imamura R Matsuda T Ikemoto S Kameya S Takeda
JOURNAL OF CELL BIOLOGY 158(6) 1097-1107 2002年9月 [査読有り]
alpha1-Syntrophin is a member of the family of dystrophin- associated proteins; it has been shown to recruit neuronal nitric oxide synthase and the water channel aquaporin-4 to the sarcolemma by its PSD-95/SAP-90, Discs-large, ZO-1 homologous doma...
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