ML Roberts DJ Wells IR Graham SA Fabb VJ Hill G Duisit K Yuasa S Takeda FL Cosset G Dickson
HUMAN MOLECULAR GENETICS 11(15) 1719-1730 2002年7月 [査読有り]
The ability to transfer the dystrophin gene stably to the skeletal muscle of DMD patients is a major confounding issue in establishing an effective gene therapy for this disease. To overcome this problem, we have examined the ability of muscle fib...
M Sakamoto K Yuasa M Yoshimura T Yokota T Ikemoto M Suzuki G Dickson Y Miyagoe-Suzuki S Takeda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293(4) 1265-1272 2002年5月 [査読有り]
The adeno-associated virus vector is a good tool for gene transfer into skeletal muscle, but the length of a gene that can be incorporated is limited. To develop a gene therapy for Duchenne muscular dystrophy, we generated a series of rod-truncate...
K Fujimori Y Itoh K Yamamoto Y Miyagoe-Suzuki K Yuasa K Yoshizaki H Yamamoto S Takeda
HUMAN GENE THERAPY 13(4) 509-518 2002年3月 [査読有り]
Duchenne muscular dystrophy (DMD) is an X-linked lethal disorder caused by a defect in the DMD gene, which encodes the cytoskeletal protein dystrophin. Utrophin is an autosomal homolog of the DMD gene product dystrophin, and augmented expression o...
S Fukada Y Miyagoe-Suzuki H Tsukihara K Yuasa S Higuchi S Ono K Tsujikawa S Takeda H Yamamoto
JOURNAL OF CELL SCIENCE 115(6) 1285-1293 2002年3月 [査読有り]
The myogenic potential of bone marrow and fetal liver cells was examined using donor cells from green fluorescent protein (GFP)-gene transgenic mice transferred into chimeric mice. Lethally irradiated X-chromosome-linked muscular dystrophy (mdx) m...
W Araki K Yuasa S Takeda K Takeda K Shirotani K Takahashi T Tabira
JOURNAL OF NEUROCHEMISTRY 79(6) 1161-1168 2001年12月 [査読有り]
Presenilin 2 (PS2) is a polytopic membrane protein that is mutated in some cases of familial Alzheimer's disease (AD). The normal functions of PS2 and its pathogenic role in AD remain unclear. We investigated the biological role of this protein in...
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