Hepatocyte transplantation is an attractive alternative to orthotopic liver transplantation. However, its application has been limited because of its short- term success only. Here we report a new approach to hepatocyte transplantation resulting i...
Y Watanabe   O Suzuki   T Haruyama   T Akaike   
JOURNAL OF CELLULAR BIOCHEMISTRY 89(2) 244-253 2003年5月
Interferon-gamma (IFN-gamma) induces cell-cycle arrest and p53-independent apoptosis in primary cultured hepatocytes. However, the detailed mechanism, including regulating molecules, is still unclear. In this study, we found that IFN-gamma induced...
Matrix metalloproteinases (MMPs) are involved in invasive cell behavior, embryonic development and organ remodeling. In this report, we investigated the role of liver-derived MMP-9 in the in vivo system at liver injury. Liver injury induced MMP-9 ...
Ajioka, I   T Akaike   Y Watanabe   
JOURNAL OF CELLULAR BIOCHEMISTRY 84(2) 249-263 2002年
Mature adult parenchymal hepatocytes can enter the S phase in the presence of growth factors such as HGF and EGF, but rarely proliferate in culture. We hypothesized that the cell cycle of hepatocytes in culture is restricted before G(2)/M phase an...