Y Watanabe   K Hirakawa   T Haruyama   T Akaike   
FEBS LETTERS 502(1-2) 63-67 2001年7月
Matrix metalloproteinase-9 (MMP-9) is produced by the inactive proform and activated by a proteolytic process. However, it has not been reported to produce the active form directly from cells, which has hindered the research to elicit the physiolo...
One of the major goals of tissue engineering is to establish an integrated organ in vivo. We have previously shown that transfection of vascular endothelial growth factor (VEGF) gene into hepatocytes promotes tissue formation by engrafted cells. H...
Shibuya, I   T Akaike   Y Watanabe   
BIOTECHNOLOGY LETTERS 22(23) 1855-1859 2000年12月
To develop a drug delivery system for acute hepatic injury, we prepared Z-Asp, a general caspase inhibitor, encapsulated in poly (DL-lactic-co-glycolic acid) (50:50) (mol/mol) nanoparticles bearing poly-(N-p-vinylbenzyl-O-beta -d-galactopyranosyl-...
Shibuya, I   T Akaike   Y Watanabe   
HEPATOLOGY 32(6) 1300-1308 2000年12月
Strict regulation of the distribution and degradation kinetics is the ultimate aim of drug delivery system. Regulation of drug delivery would increase the therapeutic efficacy and decrease the potential side effects. We encapsulated and used Z-Asp...