T Haruyama   Ajioka, I   T Akaike   Y Watanabe   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 272(3) 681-686 2000年6月
Regulation in expression and activation of proteinases is one of the most important mechanisms in organ morphogenesis. In this study, we investigated the expression of MMPs in primary hepatocytes and their roles in liver remodeling. A hepatocyte p...
Y Watanabe   Liu, X   Shibuya, I   T Akaike   
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 11(8) 833-848 2000年
Hepatocytes express the specific C-type lectin, asialoglycoprotein (ASGP) receptor, on the surface to remove the ligand-bearing proteins from circulation. The specific expression and ligand specificity are thought to be the ideal characters for th...
Background: Telomerase consists of two essential subunits, the template RNA (TR; telomerase RNA) and the catalytic subunit TERT (telomerase reverse transcriptase). Knockout mice with a mTR (mouse TR) deletion have been described and well character...
JOURNAL OF CELLULAR PHYSIOLOGY 179(1) 45-51 1999年4月
Caspases, a family of cysteine proteases, are the key effector proteins of apoptosis. These proteases cleave cellular proteins and are responsible for the destruction of the cell body during apoptosis. They are also involved in the activation of o...
A Kano   T Haruyama   T Akaike   Y Watanabe   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 257(3) 672-677 1999年4月
IFN-gamma induces cell cycle arrest and p53-independent apoptosis in primary cultured hepatocytes. However, it is not yet understood what molecules regulate the mechanism. We report here that interferon regulatory factor 1 (IRF-1) is an essential ...