Survival and proliferation of endothelial cells requires both growth factors and an appropriate extracellular matrix tip which cells can attach, In the absence of either, endothelial cells rapidly undergo apoptosis. Thus, when human microvascular ...
Y Watanabe   SW Lee   M Detmar   Ajioka, I   HF Dvorak   
ONCOGENE 14(17) 2025-2032 1997年5月
Like most other normal cells, human endothelial cells possess a limited replicative life span, and, after multiple passages in vitro, develop an arrest in cell division referred to as replicative senescence, For many cell types senescence can be d...
The mechanism by which IFN-gamma induces cell cycle arrest and cell death in primary cultured hepatocytes was examined, The cell death exhibits apoptotic characters such as the appearance of apoptotic bodies and DNA fragmentation, IFN-gamma induce...